Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.

@article{Serhan2006AntiinflammatoryAO,
  title={Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes.},
  author={Charles Nicholas Serhan and Katherine H. Gotlinger and Song Iee Hong and Yan Lu and Jeffrey N. Siegelman and Tamara Elizabeth Baer and Rong Yang and Sean P Colgan and Nicos A Petasis},
  journal={Journal of immunology},
  year={2006},
  volume={176 3},
  pages={
          1848-59
        }
}
Protectin D1, neuroprotectin D1 when generated by neural cells, is a member of a new family of bioactive products generated from docosahexaenoic acid. The complete stereochemistry of protectin D1 (10,17S-docosatriene), namely, chirality of the carbon-10 alcohol and geometry of the conjugated triene, required for bioactivity remained to be assigned. To this end, protectin D1/neuroprotectin D1 (PD1) generated by human neutrophils during murine peritonitis and by neural tissues was separated from… CONTINUE READING

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