Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages.

@article{Mayo2005AntiinflammatoryAO,
  title={Anti-inflammatory actions of melatonin and its metabolites, N1-acetyl-N2-formyl-5-methoxykynuramine (AFMK) and N1-acetyl-5-methoxykynuramine (AMK), in macrophages.},
  author={Juan C Mayo and Rosa M S{\'a}inz and Dun-xian Tan and R{\"u}diger Hardeland and Josefa Le{\'o}n and Carmen Mart{\'i}n Rodr{\'i}guez and Russell J Reiter},
  journal={Journal of neuroimmunology},
  year={2005},
  volume={165 1-2},
  pages={139-49}
}
Inflammation is a complex phenomenon involving multiple cellular and molecular interactions which must be tightly regulated. Cyclooxygenase-2 (COX) is the key enzyme that catalyzes the two sequential steps in the biosynthesis of PGs from arachidonic acid. The inducible isoform of COX, namely COX-2, plays a critical role in the inflammatory response and its over-expression has been associated with several pathologies including neurodegenerative diseases and cancer. Melatonin is the main product… CONTINUE READING
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