Anti-inflammatory actions of St. John's wort: inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha (STAT-1alpha) activation.

@article{Tedeschi2003AntiinflammatoryAO,
  title={Anti-inflammatory actions of St. John's wort: inhibition of human inducible nitric-oxide synthase expression by down-regulating signal transducer and activator of transcription-1alpha (STAT-1alpha) activation.},
  author={Elisa Tedeschi and Marta Menegazzi and Daniela Margotto and Hisanori Suzuki and Ulrich Foerstermann and Hartmut Kleinert},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2003},
  volume={307 1},
  pages={254-61}
}
St. John's wort (SJW) has been described to show anti-inflammatory properties due to its inhibitory effects on the expression of pro-inflammatory genes like cyclooxygenase-2, interleukin-6, and inducible nitric-oxide synthase (iNOS). Since iNOS plays a critical role in chronic inflammatory diseases, we have focused our attention on the regulation of iNOS expression by SJW in two different human epithelial cell lines, alveolar A549/8 and colon DLD-1 cells. SJW extract concentration dependently… CONTINUE READING

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