Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance

@article{Engelhardt1995AntiinflammatoryAA,
  title={Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance},
  author={Guenther Dr Engelhardt and Daisuke Homma and Kristina Schlegel and Rene Utzmann and C. Schnitzler},
  journal={Inflammation Research},
  year={1995},
  volume={44},
  pages={423-433}
}
The anti-inflammatory, analgesic and antipyretic properties of the new non-steroidal anti-inflammatory agent, meloxicam, were investigated in a variety of animal models and compared with the properties of piroxicam, diclofenac, indomethacin and several other NSAIDs.With respect to the total effect of a single oral dose, the anti-exudative effect of meloxicam on carrageenaninduced oedema in the rat exceeded that of all the NSAIDs included in the comparison. Additionally, meloxicam showed the… 
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239 Citations
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239 Citations

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Findings indicate that the action of meloxicam and piroxicam differs from that of diclofenac and tenidap in adjuvant arthritis in the Lewis rat.
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References

SHOWING 1-10 OF 60 REFERENCES

Meloxicam: A toxicology overview

Toxicological testing of meloxicam in animals suggests that acute oral overdosage is unlikely to cause severe toxicity in man, and the drug in animal tests exhibits potential antiarthritic action and has a wider spectrum of anti-inflammatory activity than currently available NSAIDs.

A biochemical basis for the gastrointestinal toxicity of non-steroid antirheumatoid drugs.

  • B. WhittleJ. Vane
  • Medicine, Biology
    Archives of toxicology. Supplement. = Archiv fur Toxikologie. Supplement
  • 1984
The development of nonsteroid anti-rheumatic drugs which have minimal action on prostaglandin production by the gastro-intestinal tract and exhibit reduced gastrointestinal toxicity appears to be a feasible proposition.

Biological activity of the main metabolites of meloxicam.

It can be concluded that the metabolites of Meloxicam do not change renal blood flow and therefore have no capability for nephrotoxicity, in accordance with the observations in the rat kidney during subacute and chronic toxicity studies, where no neph rotoxic effects could be detected after therapeutic doses.

Effect of a new anti-inflammatory compound, CGP 28237, on arachidonate metabolism in rat gastrointestinal tissue

CGP 28237 (5-methlysulfonylamino-6-phenoxy1-indanone), a new NSAID, is equipotent with indomethacin in the rat adjuvant arthritis test and has an outstanding gastrointestinal tolerability in this species up to the highest dose tested.

Comparative effect of antirheumatic drugs on adjuvant-induced polyarthritis in rats.

  • J. WardR. S. Cloud
  • Medicine, Biology
    The Journal of pharmacology and experimental therapeutics
  • 1966
Adjuvant arthritis of rats is established as an experimental model for testing antiartliritic drugs and it is suggested that this model would be more useful for drug evaluation with improved techniques for measuring joint swelling and tenderness.

Analgesic antipyretic drugs as antagonists of bradykinin.

The antagonism between analgesic antipyretic drugs and bradykinin was examined quantitatively, using the bronchoconstrictor response of guinea-pigs in vivo and a method of measuring the potency of this anti-bradykinIn action was developed.

An analysis of piroxicam in rodent models of arthritis

Piroxicam inhibited rat adjuvant disease and its associated manifestations, which include erosion of bone and cartilage, soft tissue swelling and disease-induced weight loss, in several rodent models of arthritis.

The effect of locally injected anti-inflammatory drugs on the synthesis of collagen and non-collagen protein of carrageenin granuloma in rats.

Distribution of [14C]meloxicam in joints of rats with adjuvant arthritis.

Using the new non-steroidal anti-inflammatory agent meloxicam (Mel), comparative investigations on pharmacokinetics and metabolism show good agreement between results in man and in the rat. To…

THE PHARMACOLOGY OF PHENYLBUTAZONE ANALOGUES

The experience gained thus far with the pyrazolidine group constitutes impressive support for the view that, in the experimental evaluation of new drugs, the classic methods of pharmacology must be supplemented by an investigation of the quantitative, that is, the chemical conditions for their activity.
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