Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.

@article{Na2010AntiinfectiveDF,
  title={Anti-infective discorhabdins from a deep-water alaskan sponge of the genus Latrunculia.},
  author={MinKyun Na and Yuanqing Ding and Bin Wang and Babu L. Tekwani and Raymond F Schinazi and Scott G Franzblau and Michelle Kelly and Robert Stone and X A Li and Daneel Ferreira and Mark T. Hamann},
  journal={Journal of natural products},
  year={2010},
  volume={73 3},
  pages={383-7}
}
Bioassay- and LC-MS-guided fractionation of a methanol extract from a new deep-water Alaskan sponge species of the genus Latrunculia resulted in the isolation of two new brominated pyrroloiminoquinones, dihydrodiscorhabdin B and discorhabdin Y (2), along with six known pyrroloiminoquinone alkaloids, discorhabdins A (3), C (4), E (5), and L (6), dihydrodiscorhabdin C (7), and the benzene derivative 8. Compounds 3, 4, and 7 exhibited anti-HCV activity, antimalarial activity, and selective… CONTINUE READING