Anti-in ammatory effects of k-opioids: relevance to rheumatoid arthritis

Abstract

Opioid drugs are not currently used in the treatment of rheumatoid arthritis, partly because of their range of side effects and because their antiinammatory (as opposed to analgesic) actions have been largely unrecognized. The synthesis of peripherally selective k-opioid agonists has allowed the analgesic and anti-inammatory effects of opioids in arthritis to be studied, while mitigating the problems of tolerance and central side effects. They are powerfully anti-inammatory in a dose-dependent, time-dependent, stereoselective and antagonist reversible manner.1 This brief report examines the anti-inammatory effects of k-opioids, both centrally active and peripherally selective k-opioid agonists, with particular relevance to rheumatoid arthritis, and reports data on the mechanisms responsible for the anti-arthritic effects of k-opioids in adjuvant arthritis. Opioids exert their diverse physiological effects through three distinct membrane-bound receptor subtypes mu (μ), delta (d) and kappa (k) Address for correspondence: Judith S Walker, School of Physiology and Pharmacology, University of New South Wales, Sydney NSW 2052, Australia. E-mail: JudithW@medscape.com Anti-in ammatory effects of k-opioids: relevance to rheumatoid arthritis

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Cite this paper

@inproceedings{Walker2003AntiinAE, title={Anti-in ammatory effects of k-opioids: relevance to rheumatoid arthritis}, author={Judith S. Walker and J Walker}, year={2003} }