Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice

@article{Amiri1994AntiimmunoglobulinET,
  title={Anti-immunoglobulin E treatment decreases worm burden and egg production in Schistosoma mansoni-infected normal and interferon gamma knockout mice},
  author={Payman Amiri and Mary Haak-Frendscho and Ken Robbins and James H McKerrow and Timothy Stewart and Paula Jardieu},
  journal={The Journal of Experimental Medicine},
  year={1994},
  volume={180},
  pages={43 - 51}
}
The immunoglobulin E (IgE) response is generally considered an essential component of the host defense against parasitic helminths such as Schistosoma mansoni. In contrast, work on antischistosome vaccines suggests that interferon gamma (IFN-gamma) is the critical immune mediator for vaccine-induced immunity to the parasite. In this study, the total IgE response to a primary S. mansoni infection was suppressed by anti-IgE treatment in both normal mice and in mice with defective IFN genes (gene… CONTINUE READING

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