Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis.

@article{Lider1988AntiidiotypicNI,
  title={Anti-idiotypic network induced by T cell vaccination against experimental autoimmune encephalomyelitis.},
  author={Ofer Lider and Tamara Reshef and Evelyne B{\'e}raud and Avraham Ben-Nun and Irun R. Cohen},
  journal={Science},
  year={1988},
  volume={239 4836},
  pages={181-3}
}
In a study of the mechanism of resistance to autoimmune disease induced by T cell vaccination, rats were vaccinated against experimental autoimmune encephalomyelitis (EAE) by injecting them once in the hind footpads with a subencephalitogenic dose (10(4)) of a clone of T lymphocytes specific for myelin basic protein (BP). The response to vaccination was assayed by challenging the rats with an encephalitogenic dose (3 X 10(6)) of T lymphocytes of this BP-specific clone. Five to six days after… CONTINUE READING
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