Anti-idiotypic antibodies that react with microtubule-associated proteins are present in the sera of rabbits immunized with synthetic peptides from tubulin's regulatory domain.

@article{Rivas1988AntiidiotypicAT,
  title={Anti-idiotypic antibodies that react with microtubule-associated proteins are present in the sera of rabbits immunized with synthetic peptides from tubulin's regulatory domain.},
  author={Coralia I. Rivas and Juan C. Vera and Ricardo Benjamin Maccioni},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 16},
  pages={6092-6}
}
A fundamental question in microtubule research is how the interactions of tubulin subunits with microtubule-associated proteins (MAPs) are controlled. The answer should provide insight into the regulation of the cellular processes in which microtubules are implicated. Previous work demonstrated the interaction of MAPs with a 4-kDa C-terminal domain of tubulin alpha and beta subunits. Synthetic peptides from the variable region of the 4-kDa C-terminal moiety of tubulin subunits, alpha-(430-441… CONTINUE READING