Anti-idiotypic Antibodies against BP-IgG Prevent Type XVII Collagen Depletion


Bullous pemphigoid (BP) mainly targets type XVII collagen (COL17). Intravenous immunoglobulin (IVIg) is used to treat numerous autoimmune diseases, including BP. The major mechanism of action for IVIG is thought to be its immunomodulatory effect. However, little is known about the precise mechanisms of IVIg in BP. We investigate the cellular effects of IVIg… (More)
DOI: 10.3389/fimmu.2017.01669