Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation.

@article{Watts2013AntihypertrophicAA,
  title={Anti-hypertrophic and anti-oxidant effect of beta3-adrenergic stimulation in myocytes requires differential neuronal NOS phosphorylation.},
  author={Vabren L Watts and Fernando M Sepulveda and Oscar H. Cingolani and Alice Sheng-Sheng Ho and Xiaolin Niu and Rosa Kim and Karen L. Miller and Koenraad M Vandegaer and Djahida Bedja and Kathleen L. Gabrielson and Gerald A Rameau and Brian O'Rourke and David A. Kass and Lili A. Barouch},
  journal={Journal of molecular and cellular cardiology},
  year={2013},
  volume={62},
  pages={8-17}
}
RATIONALE Stimulation of β3-adrenoreceptors (β3-AR) blunts contractility and improves chronic left ventricular function in hypertrophied and failing hearts in a neuronal nitric oxide synthase (nNOS) dependent manner. nNOS can be regulated by post-translational modification of stimulatory phosphorylation residue Ser1412 and inhibitory residue Ser847. However, the role of phosphorylation of these residues in cardiomyocytes and β3-AR protective signaling has yet to be explored. OBJECTIVE We… CONTINUE READING

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