Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action.

  title={Anti-hyperlipidemic sesquiterpenes and new sesquiterpene glycosides from the leaves of artichoke (Cynara scolymus L.): structure requirement and mode of action.},
  author={Hiroshi Shimoda and Kiyofumi Ninomiya and Norihisa Nishida and Tomoe Yoshino and Toshio Morikawa and Hisashi Matsuda and Masayuki Yoshikawa},
  journal={Bioorganic \& medicinal chemistry letters},
  volume={13 2},

Ursane-type triterpene oligoglycosides with anti-hepatosteatosis and anti-hyperlipidemic activity from the leaves of Ilex paraguariensis A. St.-Hil.

In vivo assay of the methanol extract of Ilex paraguariensis revealed that 7 and 9 showed anti-hyperlipidemic activities in olive oil-treated mice, suggesting that the saponin constituents of I. paraguaris could be valuable bioactive marker for the anti-obesogenic activity.

Inhibitory effects of cynaropicrin and related sesquiterpene lactones from leaves of artichoke (Cynara scolymus L.) on induction of iNOS in RAW264.7 cells and its high-affinity proteins

The methanolic extract of the leaves of artichoke was found to inhibit nitric oxide production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells and suggested that these sesquiterpene lactones inhibited the LPS-induced iNOS expression via the suppression of the JAK-STAT signaling pathway in addition to the κNF-κB signaling pathway.

Sesquiterpene Lactones from Cynara cornigera: Acetyl Cholinesterase Inhibition and In Silico Ligand Docking.

Seven sesquiterpene lactones were isolated from an aqueous methanol plant extract, including a new halogenated metabolite (1), the naturally isolated compound sibthorpine (2), and five metabolites isolated for the first time from C. cornigera.

The First Guaian-12-oic Acid Glucopyranosyl Ester and Other Constituents from Picris rhagadioloides (L.) Desf. (Asteraceae)

This is the first time that the known phenolics syringaldehyde and syringaresinol, as well as the known sesquiterpene lactones glucozaluzanin C, cichorioside C and hypochoeroside A have been described from a Picris species.

Guaianolides from the Aerial Parts of Centaurea Hololeuca

Seven guaianolides were isolated from the acetone extract of the aerial parts of Centaurea hololeuca Boiss and showed significant antifeedant activity at 100 ppm, whereas at this concentration cebellin G and 15-deschloro-15-hydroxychlorojanerin stimulated feeding and deterred feeding at high concentrations.

Antispasmodic activity of fractions and cynaropicrin from Cynara scolymus on guinea-pig ileum.

The results confirm the popular use of artichoke for the treatment of gastrointestinal disturbances, and encourage new studies on this compound, in order to obtain new antispasmodic agents.

Antidiabetogenic constituents from the Thai traditional medicine Cotylelobium melanoxylon.

The methanolic extracts from the wood and bark of Cotylelobium melanoxylon were found to inhibit plasma glucose elevation after sucrose loading in rats and triglyceride elevation after olive oil

A New Sesquiterpene Lactone from the Leaves of Cynara scolymus (Compositae)

A new guaiane-type sesquiterpene lactone, named 3β, 8α, 11α, 13-tetrahydroxy-10 (14)-guaien-1α, 4β, 5α, 6βH-6α, 12-olide (1), together with a known sesquiterpene lactone, cynarinin A (2), were



Sesquiterpene glycosides and saponins from Cynara cardunculus L.

A new guaiane-type sesquiterpene glycoside, cynaroside A, seven new ursane-type saponins, cynarasaponins A-G, and three new oleanase-type saponins, cynarasaponins H-J, have been isolated from Cynara

Flavonol glycosides and steroidal saponins from the leaves of Cestrum nocturnum and their cytotoxicity.

Phytochemical analysis of the leaves of Cestrum nocturnum (Solanaceae) resulted in the isolation of two new flavonol glycosides (1, 2) and seven steroidal saponins (3-9), including four new ones (4,

Studies on the constituents of Palmae plants. I: The constituents of Trachycarpus fortunei (Hook.) H. Wendl. (1)

The constituents of the leaves, stems and underground parts of Trachycarpus fortunei (HOOK.) H. WENDL. (Palmae) have been investigated. Glucoluteolin (3), luteolin 7-O-rutinoside (=scolymoside, 4)

Increase in choleresis by means of artichoke extract.

Studies on Sesquiterpenes from Macroclinidium trilobum MAKINO. I

Four new guaiane-type sesquiterpene glycosides, macroclinisides F (II), G (III), H (IV) and I (V), and a new phenyl propanoid glycoside, 4-allyl-2, 6-dimethoxyphenol glucoside (VI), have been

Inhibition of cholesterol biosynthesis in primary cultured rat hepatocytes by artichoke (Cynara scolymus L.) extracts.

  • R. Gebhardt
  • Biology
    The Journal of pharmacology and experimental therapeutics
  • 1998
It is demonstrated that artichoke extracts may inhibit hepatic cholesterol biosynthesis in an indirect but efficient manner and, thus, may contribute via this action to the recently confirmed hypolipidemic influence of this phytopharmacon in man.

Activity of artichoke leaf extract on reactive oxygen species in human leukocytes

Cynarin, caffeic acid, chlorogenic acid, and luteolin, constituents of artichoke leaf extract, also show a concentration-dependent inhibitory activity in the above models, contributing to the antioxidant activity of the extract in human neutrophils.