Anti-hyperglycemic effect of Potentilla discolor decoction on obese-diabetic (Ob-db) mice and its chemical composition.

@article{Song2012AntihyperglycemicEO,
  title={Anti-hyperglycemic effect of Potentilla discolor decoction on obese-diabetic (Ob-db) mice and its chemical composition.},
  author={Chengwu Song and Long-sheng Huang and Lin Rong and Zhiwen Zhou and Xiaohui Peng and Shanggong Yu and N. Fang},
  journal={Fitoterapia},
  year={2012},
  volume={83 8},
  pages={
          1474-83
        }
}
Potentilla discolor is used as an ethnomedicine in treatments of diabetes mellitus in China for years. In the present study, the anti-hyperglycemic effects of a clinical active extract (decoction) from P. discolor were investigated in Ob-db mice. Four week's treatment of P. discolor decoction ameliorated the development of hyperlipidemia, lipid peroxidation and hyperglycemia associated with hyperphagia and polydypsia in Ob-db mice. P. discolor significantly attenuated the increase of blood… Expand
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TLDR
Experimental results highlighted the hypoglycemic and hypolipidemic properties of the two extracts from Potentilla discolor Bunge on diabetes and its complications, possibly through a strong antioxidant activity and a protective action on β-cells. Expand
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It was found that the standardized extract of P. discolor (EPD) had little effect on the glucose levels of normal mice, while a dose‐dependent hypoglycemic effect was observed in diabetic mice, suggesting EPD extract may offer an alternate treatment for diabetes. Expand
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