Anti-hyperglycemic effect of 11-hydroxypalmatine, a palmatine derivative from Stephania glabra tubers

@article{Semwal2010AntihyperglycemicEO,
  title={Anti-hyperglycemic effect of 11-hydroxypalmatine, a palmatine derivative from Stephania glabra tubers},
  author={D. Semwal and U. Rawat and R. Semwal and Randhir Singh and Gur Jas Preet Singh},
  journal={Journal of Asian Natural Products Research},
  year={2010},
  volume={12},
  pages={105 - 99}
}
  • D. Semwal, U. Rawat, +2 authors Gur Jas Preet Singh
  • Published 2010
  • Chemistry, Medicine, Biology
  • Journal of Asian Natural Products Research
  • A palmatine derivative, named 11-hydroxypalmatine (4), has been isolated from the tubers of Stephania glabra, together with three known alkaloids, palmatine (1), dehydrocorydalmine (2), and stepharanine (3). The structures of the compounds were elucidated by means of spectroscopic analysis including 2D NMR experiments. The hypoglycemic activity of 4 was evaluated against alloxan-induced diabetic mice. The test compound was administered at doses of 25, 50, and 100 mg/kg, p.o., 36 h after alloxan… CONTINUE READING
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