Anti-hyperglycemic action of apigenin-6-C-β-fucopyranoside from Averrhoa carambola.

@article{Cazarolli2012AntihyperglycemicAO,
  title={Anti-hyperglycemic action of apigenin-6-C-β-fucopyranoside from Averrhoa carambola.},
  author={Luisa H. Cazarolli and Virg{\'i}nia Demarchi Kappel and Danielle Fontana Pereira and Henrique Hunger Moresco and In{\^e}s Maria Costa Brighente and Moacir Geraldo Pizzolatti and F{\'a}tima Regina Mena Barreto Silva},
  journal={Fitoterapia},
  year={2012},
  volume={83 7},
  pages={1176-83}
}
A stimulatory effect of apigenin-6-C-β-fucopyranoside (1) on glucose uptake was observed when rat soleus muscle was incubated with 1, 10 and 100 μM of this flavonoid glycoside. The presence of specific insulin signaling inhibitors, such as wortmannin, an inhibitor of phosphoinositide 3-kinase (PI3K), RO318220, an inhibitor of protein kinase C (PKC), PD98059, an inhibitor of mitogen-activated protein kinase (MEK), and HNMPA(AM)₃, an insulin receptor tyrosine kinase activity inhibitor showed that… CONTINUE READING