Anti-hyperglycaemic effect of Phragmenthera austroarabica A.G.Mill. & J.A.Nyberg extract in streptozotocin-induced diabetes in rats

  title={Anti-hyperglycaemic effect of Phragmenthera austroarabica A.G.Mill. \& J.A.Nyberg extract in streptozotocin-induced diabetes in rats},
  author={Abeer Hanafy and Jihan M Badr},
  journal={Natural Product Research},
  pages={2351 - 2354}
This study was undertaken to investigate the hypoglycaemic activity of Phragmenthera austroarabica A.G.Mill. & J.A.Nyberg extract and evaluate its possible antioxidant and anti-hyperlipidaemic effect in type 2 diabetic animal model. Type 2 diabetes was induced by a high-fat diet followed by injection with streptozotocin. Diabetic adult male Wistar rats were allocated into three groups and treated with pioglitazone HCl (PIO) or the extract of P. austroarabica A.G.Mill. & J.A.Nyberg (250 or 500… 
Anticonvulsant and Neuroprotective Activities of Phragmanthera austroarabica Extract in Pentylenetetrazole-Kindled Mice
It is concluded that P. austroarabica extract ameliorated seizure activity and protected cortical and hippocampal neurons against pentylenetetrazole-induced kindling in mice.
Polarography as a technique of choice for the evaluation of total antioxidant activity: The case study of selected Coprinus Comatus extracts and quinic acid, their antidiabetic ingredient
Direct current (DC) polarographic HydroxoPerhydroxo Mercury(II) Complex (HPMC) assay based on decrease of anodic limiting current originating from HPMC formation in alkaline solutions of hydrogen peroxide at potential of mercury dissolution, observed upon gradual addition of antioxidants, was applied herein for the estimation of the natural products' antioxidativity.


Antioxidant activities and flavonoid contents of selected plants belonging to Family Loranthaceae
The methanolic extract of three parasitic plants belonging to family Loranthaceae ( Plicosepalus acacia , Plicosepalus curviflorus and Phragmanthera austro arabica ) were investigated for their
Regeneration of coenzyme Q9 redox state and inhibition of oxidative stress by Rooibos tea (Aspalathus linearis) administration in carbon tetrachloride liver damage.
Improved regeneration of coenzyme Q9 redox state and inhibition of oxidative stress in CCl4-damaged livers may explain the beneficial effect of antioxidant therapy.
Antioxidant and prooxidant effects of quercetin on glyceraldehyde-3-phosphate dehydrogenase.
Increase in Total Antioxidant Capacity of Plasma despite High Levels of Oxidative Stress in Uncomplicated Type 2 Diabetes Mellitus
The total antioxidant capacity of plasma was increased, despite high levels of oxidative stress, in patients with uncomplicated type 2 diabetes, in order to understand the interactions between its components and the diabetic milieu.
Determination of the relative contribution of quercetin and its glucosides to the antioxidant capacity of onion by cyclic voltammetry and spectrophotometric methods.
The reducing capacity of onions determined by the CV method was 3-fold and about four times lower when compared to the antioxidant capacity evaluated by the TEAC method and that formed by lipid-soluble compounds (ACL) provided by PCL, respectively.
The relative antioxidant activities of plant-derived polyphenolic flavonoids.
The relative antioxidant activities, against radicals generated in the aqueous phase, of a range of plant-derived polyphenolic flavonoids, constituents of fruit, vegetables, tea and wine, have been assessed and compounds such as quercetin and cyanidin have antioxidant potentials four times that of Trolox, the vitamin E analogue.
Structure-antioxidant activity relationships of flavonoids and phenolic acids.
Reactive Oxygen and Nitrogen Species in Pathogenesis of Vascular Complications of Diabetes
  • S. Son
  • Medicine, Biology
    Diabetes & metabolism journal
  • 2012
It has recently been suggested that diabetic subjects with vascular complications may have a defective cellular antioxidant response against the oxidative stress generated by hyperglycemia, which raises the concept that antioxidant therapy may be of great benefit to these subjects.
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
It is proposed here that the hyperglycemia- induced, and possibly FFA-induced, activation of stress pathways plays a key role in the development of not only the late complications in type 1 and type 1 diabetes, but also the insulin resistance and impaired insulin secretion seen in type 2 diabetes.
Are oxidative stress activated signalling pathways mediators of insulin resistance and cell dysfunction? Diabetes
  • 52:1–8.
  • 2003