Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).

@article{Mendes1998AntihyperalgesicPO,
  title={Anti-hyperalgesic properties of the extract and of the main sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae).},
  author={G L Mendes and Adair Roberto Soares dos Santos and Maria Martha Campos and Karla S. Tratsk and Rosendo Augusto Yunes and Valdir Cechinel Filho and Jo{\~a}o Batista Calixto},
  journal={Life sciences},
  year={1998},
  volume={63 5},
  pages={369-81}
}
This study analyses the anti-hyperalgesic properties of the hydroalcoholic extract (HE) and the sesquiterpene polygodial isolated from the barks of Drymis winteri (Winteraceae). The HE (10 to 60 mg kg(-1), i.p. or 100 to 600 mg kg(-1), p.o.), 4 h prior, produced significant inhibition of abdominal constrictions caused by i.p. injection of acetic acid, kaolin and zymosan in mice. The mean ID50s were: 21.4, 33.7 and 36.6 mg kg(-1); 173.0, 123.0 and 366.0 mg kg(-1), by i.p. and by oral route… CONTINUE READING