Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model

@inproceedings{Eksteen2017AntihumanPA,
  title={Anti-human platelet antigen (HPA)-1a antibodies may affect trophoblast functions crucial for placental development: a laboratory study using an in vitro model},
  author={Mariana Eksteen and G\oril Heide and Heidi Tiller and Yan Zhou and Nora Hersoug Nedberg and Inigo Martinez-Zubiaurre and Anne Husebekk and Bj\orn R Skogen and Tor Brynjar Stuge and Mette Kj{\ae}r},
  booktitle={Reproductive biology and endocrinology : RB&E},
  year={2017}
}
BACKGROUND Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a bleeding disorder caused by maternal antibodies against paternal human platelet antigens (HPAs) on fetal platelets. Antibodies against HPA-1a are accountable for the majority of FNAIT cases. We have previously shown that high levels of maternal anti-HPA-1a antibodies are associated with clinically significant reduced birth weight in newborn boys. Chronic inflammatory placental lesions are associated with increased risk of… CONTINUE READING
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