Anti-human neutrophil antigen-3a induced transfusion-related acute lung injury in mice by direct disturbance of lung endothelial cells.

@article{Bayat2013AntihumanNA,
  title={Anti-human neutrophil antigen-3a induced transfusion-related acute lung injury in mice by direct disturbance of lung endothelial cells.},
  author={Behnaz Bayat and Yudy Tjahjono and Akylbek Sydykov and Silke Werth and Stefan Hippenstiel and Nobert Weissmann and Ulrich Sachs and S. H. Urip Santoso},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2013},
  volume={33 11},
  pages={
          2538-48
        }
}
OBJECTIVE Antibodies against human neutrophil antigen-3a (HNA-3a) located on choline transporter-like protein 2 induce severe transfusion-related acute lung injury (TRALI). This study aims to identify the mechanism implicated in anti-HNA-3a-mediated TRALI. APPROACH AND RESULTS Our analysis shows that anti-HNA-3a recognizes 2 choline transporter-like protein 2 isoforms (P1 and P2) on human microvascular endothelial cells from lung blood vessels but reacts only with the P1 isoform on… CONTINUE READING
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Citations

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Molecular Genetics of the Human Neutrophil Antigens.

  • Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie
  • 2018

The Pathogenic Involvement of Neutrophils in Acute Respiratory Distress Syndrome and Transfusion-Related Acute Lung Injury.

  • Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie
  • 2018

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