Anti-human immunodeficiency virus type 1 human monoclonal antibodies that bind discontinuous epitopes in the viral glycoproteins can identify mimotopes from recombinant phage peptide display libraries.

@article{Boots1997AntihumanIV,
  title={Anti-human immunodeficiency virus type 1 human monoclonal antibodies that bind discontinuous epitopes in the viral glycoproteins can identify mimotopes from recombinant phage peptide display libraries.},
  author={Lynn J. Boots and Philip M. McKenna and Belinda Arnold and Paul M. Keller and Miroslaw K. Gorny and Susan Zolla-Pazner and James E Robinson and Anthony J. Conley},
  journal={AIDS research and human retroviruses},
  year={1997},
  volume={13 18},
  pages={1549-59}
}
A phage display library screening approach was used to identify peptide sequences that could bind to anti-HIV-1 MAbs whose binding specificities are complex. Most of the antibodies used recognize discontinuous epitopes in gp120 and one recognizes gp41. Both a 15-mer and a 21-mer display library (each with a complexity of greater than 60 x 10[6]) and two constrained, V3 region-biased libraries, all expressed as recombinant pIII protein of filamentous phage, were used. The unmapped anti-gp120… CONTINUE READING
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