Anti-herpes simplex virus activity of n-docosanol correlates with intracellular metabolic conversion of the drug.

@article{Pope1996AntiherpesSV,
  title={Anti-herpes simplex virus activity of n-docosanol correlates with intracellular metabolic conversion of the drug.},
  author={Laura E. Pope and John F. Marcelletti and L R Katz and David H. Katz},
  journal={Journal of lipid research},
  year={1996},
  volume={37 10},
  pages={2167-78}
}
The 22-carbon fatty alcohol, n-docosanol, exhibits in vitro antiviral activity against several lipid-enveloped viruses including herpes simplex viruses 1 and 2 by a mechanism that interferes with normal viral entry into target cells. We previously reported that mammalian cells incorporate significant quantities of radiolabeled n-docosanol. Herein, we report… CONTINUE READING