Anti-herpes simplex virus activity of alkaloids isolated from Stephania cepharantha.

@article{Nawawi1999AntiherpesSV,
  title={Anti-herpes simplex virus activity of alkaloids isolated from Stephania cepharantha.},
  author={As’ari Nawawi and Chao-Mei Ma and Norio Nakamura and Masao Hattori and Masuyoshi Kurokawa and Kimiyasu Shiraki and Noriaki Kashiwaba and Masahide Ono},
  journal={Biological & pharmaceutical bulletin},
  year={1999},
  volume={22 3},
  pages={
          268-74
        }
}
By screening water and MeOH extracts of 30 Chinese medicinal plants for their anti-herpes simplex virus (HSV)-1 activity, a MeOH extract of the root tubers of Stephania cepharantha HAYATA showed the most potent activity on the plaque reduction assay with an IC50 value of 18.0 microg/ml. Of 49 alkaloids isolated from the MeOH extract, 17 alkaloids were found to be active against HSV-1, including 13 bisbenzylisoquinoline, 1 protoberberine, 2 morphinane and 1 proaporphine alkaloids, while… CONTINUE READING
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