Anti-glutamate therapy in amyotrophic lateral sclerosis: a trial using lamotrigine.

@article{Eisen1993AntiglutamateTI,
  title={Anti-glutamate therapy in amyotrophic lateral sclerosis: a trial using lamotrigine.},
  author={A. Eisen and Helen Stewart and Michael Schulzer and Diane Cameron},
  journal={The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques},
  year={1993},
  volume={20 4},
  pages={297-301}
}
Glutamate excitotoxicity is implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). We report the results of a double blind, placebo controlled, trial using 100 mg of oral daily lamotrigine (3,5-diamino-6-(2,3 dichlorophenyl)-1,2,4-triazine) which inhibits glutamate release. 67 patients were entered and at trial termination of 1.5 years 15 had withdrawn (9 active and 6 placebo) and 12 had died (6 active and 6 placebo). Mean age at entry was 57.5 years for the active and 58.6… CONTINUE READING

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