Anti-genes: siRNA, ribozymes and antisense.

  title={Anti-genes: siRNA, ribozymes and antisense.},
  author={Kevin J. Scanlon},
  journal={Current pharmaceutical biotechnology},
  volume={5 5},
Scientists have been working on strategies to selectively turn off specific genes in diseased tissues for the past thirty years. In the 1980's, oligodeoxynucleotides (ODNs) with unique chemistries were tested with model systems both in vitro and in vivo with varying degrees of success. In the 1990's, ribozymes with both antisense and catalytic properties… CONTINUE READING