Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats.

@article{Chong2006AntifibroticEO,
  title={Anti-fibrotic effects of thalidomide on hepatic stellate cells and dimethylnitrosamine-intoxicated rats.},
  author={Lee-Won Chong and Yi-Chao Hsu and Yung-Tsung Chiu and Kuo-ching Yang and Y T Huang},
  journal={Journal of biomedical science},
  year={2006},
  volume={13 3},
  pages={403-18}
}
Tumor necrosis factor-alpha (TNF-alpha) plays a central role in cellular necrosis, apoptosis, organ failure, tissue damage, inflammation and fibrosis. These processes, occurring in liver injury, may lead to cirrhosis. Thalidomide, alpha-N-phthalidoglutarimide, (C(13)H(10)N(2))(4), has been shown to have immunomodulatory and anti-inflammatory properties, possibly mediated through its anti-TNF-alpha effect. In this study, we investigated the in vitro and in vivo effects of thalidomide on hepatic… CONTINUE READING

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