Anti-fertility and abortifacient potential of hydroalcoholic leaves extract of Alstonia scholaris in female rats: An ethnomedicine used by Papua women in New Guinea

@article{Choudhary2017AntifertilityAA,
  title={Anti-fertility and abortifacient potential of hydroalcoholic leaves extract of Alstonia scholaris in female rats: An ethnomedicine used by Papua women in New Guinea},
  author={M. Choudhary and S. Rani and Pallavi Sharma and N. Choudhary and Vikas Budhwaar},
  journal={Bulletin of Faculty of Pharmacy, Cairo University},
  year={2017},
  volume={55},
  pages={123-127}
}
Abstract Aim of the study Alstonia scholaris Linn. (Family: Apocynaceae) commonly known as Devilʼs tree or Saptaparna tree, is traditionally used by the women of Papua New Guinea to induce abortion. Aim of the present study is to investigate the anti-fertility potential of hydro-alcoholic leaves extract of Alstonia scholaris Linn. (HAAS) in female rats. Materials and methods The anti-fertility activity of HAAS administered. at 250 and 500 mg/kg doses was evaluated in three animal models. In… Expand
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References

SHOWING 1-10 OF 31 REFERENCES
Contraceptive, estrogenic and anti-estrogenic potentials of methanolic root extract of Carpolobia lutea in rodents.
TLDR
In ovariectomized immature young rats, the extract showed estrogenic effect in low doses while in high doses, it showed anti-estrogenic effect, which agrees with the traditional use of Carpolobia lutea in the control of fertility. Expand
Effect of Alstonia scholaris bark extract on testicular function of Wistar rats.
TLDR
At the dose level employed, Alstonia scholaris bark extract has a significant antifertility effect in male rats; the primary site of action may be post meiotic germ cells (Step 19 spermatids). Expand
Effect of Achyranthes aspera L. on fetal abortion, uterine and pituitary weights, serum lipids and hormones.
TLDR
The methanolic leaves extract of Achyranthes aspera possesses anti-fertility activity, which might be exploited to prevent unwanted pregnancy and control the ever-increasing population explosion. Expand
Phytochemical screening and pharmacological evaluations for the antifertility effect of the methanolic root extract of Rumex steudelii.
TLDR
Observations suggest that the methanolic extract of the roots of this plant, Rumex steudelii, has antif fertility effect and is safe at the effective antifertility doses employed in this study. Expand
EVALUATION OF ANTIFERTILITY POTENTIAL OF CALOTROPIS GIGANTEA LINN. IN FEMALE ALBINO RATS.
TLDR
Though the extracts of Calotropis gigantea Linn are highly toxic at higher doses yet they exhibit potential to be elucidated as female antifertility agents with proper control of toxicity, the findings suggest that the extracts are strong antiestrogenic and antiprogestagenic. Expand
Review of the phytochemical, pharmacological and toxicological properties of Alstonia Scholaris Linn. R. Br (Saptaparna)
  • M. Baliga
  • Medicine
  • Chinese journal of integrative medicine
  • 2012
TLDR
The bark and leaf extract when administered orally did not induce lethality or adverse affects at the limit doses of 2 000 mg/kg body weight, however when administered intraperitoneally at high concentrations, the extract showed systemic and developmental toxicities. Expand
Antifertility and hormonal properties of flavones of Striga orobanchioides.
TLDR
The two flavones, apigenin and luteolin, isolated from Striga orobanchioides, were investigated for endocrine and contraceptive properties and exhibited estrogenic properties at their contraceptive dose level when given alone, however, along with ethinyl estradiol they exhibited slight anti-estrogenic activity. Expand
Antioxidant anti-inflammatory activity of Alstonia scholaris R.Br. stem bark extract
ABSTRACT Background: The plant Alstonia scholaris R.Br. (Labiatae) is widely cultivated throughout India. The bark of this tree is medicinally used as an astringent, tonic, anthelmintic, antiperiodicExpand
REVIEW ON ETHNOBOTANY, PHYTOCHEMICAL AND PHARMACOLOGICAL PROFILE OF ALSTONIA SCHOLARIS
Alstonia scholaris Linn. , which is popularly known as the “Saptaparni” or the Devil tree, which are used as a well known remedy for the treatment of various types of di sorders in the Ayurvedic,Expand
Effect of ethanol extract of Rivea hypocrateriformis on the estrous cycle of the rat.
TLDR
Restoration of normal estrous cycles after withdrawal of treatment indicate the reversible effect of ethanol extract in rats, indicating the inhibition of steroidogenesis of cholesterol by ovarian endocrine tissues. Expand
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