Anti-estrogenic activity of mansonone G and mansorin A derivatives

  title={Anti-estrogenic activity of mansonone G and mansorin A derivatives},
  author={Ali M El-Halawany and Riham Salah El Dine and Masao Hattori},
  journal={Pharmaceutical Biology},
  pages={948 - 954}
Abstract Context: Mansonone G and mansorin A are major bioactive constituents from Mansonia gagei Drumm (Sterculiaceae) wood, and their mild anti-estrogenic activity was reported previously by the authors. Objective: In order to increase the potency of their anti-estrogenic effect and to clarify their binding way to estrogen receptor on a molecular level, several derivatives of both compounds will be prepared and a docking study of the original compounds and their derivatives on estrogen… Expand
7 Citations
CBMG, a novel derivative of mansonone G suppresses adipocyte differentiation via suppression of PPARγ activity.
A novel MG derivative, chlorobenzoyl MG (CBMG) may have beneficial applications in the control of obesity through the suppression of PPARγ-induced adipocyte differentiation and lipid accumulation. Expand
Anticancer Profiling for Coumarins and Related O-Naphthoquinones from Mansonia gagei against Solid Tumor Cells In Vitro
Mansorin-II synergizes the anticancer effect of paclitaxel in colorectal cancer cells, which might be partially attributed to enhancing its cellular entrapment via inhibiting P-gp efflux pump. Expand
Allyl and prenyl ethers of mansonone G, new potential semisynthetic antibacterial agents.
Four natural 1,2-naphthoquinones: mansonones C, E, G, and H were isolated from the dichloromethane extract of Mansonia gagei Drumm and converted to eight ether and four ester analogues, which exhibited better activity against Staphylococcus aureus with MIC sixty-four times better than their natural compound. Expand
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Molecular recognition of naphthoquinone-containing compounds against human DNA topoisomerase IIα ATPase domain: A molecular modeling study
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Butoxy Mansonone G Inhibits STAT3 and Akt Signaling Pathways in Non-Small Cell Lung Cancers: Combined Experimental and Theoretical Investigations
Mansonone G (MG), a naturally occurring quinone-containing compound, and its semi-synthetic ether derivatives were subjected to investigate the anticancer effects on human NSCLC cell lines expressing wild-type EGFR and mutant EGFR to reveal that MG3 induces a caspase-dependent apoptosis mechanism. Expand
Ethoxy mansonone G as an anticancer agent in estrogen receptor‐positive and endocrine‐resistant breast cancer
To study anticancer effects, underlying mechanism and safety of ethoxy mansonone G (EMG) which is the potent derivative of mansonone G (MG) in breast cancer cells.


Anti-estrogenic activity of mansorins and mansonones from the heartwood of Mansonia gagei DRUMM.
1,2-Naphthoquinones (mansonones) and Mansonones F and S showed the most potent estrogen binding and estrogen antagonistic effects. Expand
Cytotoxic effects of mansonone E and F isolated from Ulmus pumila.
Two sesquiterpenoids were isolated from the dried root bark of Ulmus pumila and their antiproliferative activities on human tumor cells were evaluated in vitro, showing that ME had more potent cytotoxic effects on four tumor cell lines. Expand
Antifungal, antioxidant and larvicidal activities of compounds isolated from the heartwood of Mansonia gagei
Mansonone C was found to be the most interesting compound with antifungal activities against Cladosporium cucumerinum and Candida albicans as well as for its larvicidal properties against Aedes aegypti and radical scavenging properties in a DPPH assay. Expand
Coumarins from the heartwoods of Mansonia gagei Drumm.
Three coumarins and three known mansonones were isolated from the heartwood of Mansonia gagei Drumm and the cytotoxicity of the isolated compounds against brine shrimp Artemia salina Linn was evaluated. Expand
New screening methods for chemicals with hormonal activities using interaction of nuclear hormone receptor with coactivator.
It is demonstrated that the measurement of interaction between steroid hormone receptor and coactivator serves as a useful tool for identifying chemicals that interact with steroid receptors. Expand
Molecular basis of agonism and antagonism in the oestrogen receptor
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Phytoestrogens: the biochemistry, physiology, and implications for human health of soy isoflavones.
  • K. Setchell
  • Biology, Medicine
  • The American journal of clinical nutrition
  • 1998
The importance of a plant-based diet is evident from the current dietary recommendations that emphasize an increase in the proportion and amount of fruit and vegetables that should be consumed, and interpretation of the role of individual components of the diet is difficult from epidemiologic and dietary studies. Expand
Supplementation with isoflavonoid phytoestrogens does not alter serum lipid concentrations: a randomized controlled trial in humans.
This study does not support the hypothesis that isoflavonoid phytoestrogens can improve the serum lipids, at least in subjects with average serum cholesterol concentrations, and it is concluded that estrogens can lower serum LDL cholesterol and raise HDL cholesterol. Expand
Structure-activity relationship study of a diverse set of estrogen receptor ligands (I) using MultiCASE expert system.
The MultiCASE expert system was used to construct a quantitative structure-activity relationship model to screen chemicals with estrogen receptor (ER) binding potential and supported the previous hypothesis that a 6 A distant descriptor may describe a ligand-binding site on an ER. Expand
The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site
The various elements in this model for the binding of steroidal estrogens by the estrogen receptor are consistent with evidence emerging from the crystal structures of related nuclear hormone receptor ligand complexes. Expand