Anti-estrogenic activity of mansonone G and mansorin A derivatives

@article{ElHalawany2013AntiestrogenicAO,
  title={Anti-estrogenic activity of mansonone G and mansorin A derivatives},
  author={Ali M El-Halawany and Riham Salah El Dine and Masao Hattori},
  journal={Pharmaceutical Biology},
  year={2013},
  volume={51},
  pages={948 - 954}
}
Abstract Context: Mansonone G and mansorin A are major bioactive constituents from Mansonia gagei Drumm (Sterculiaceae) wood, and their mild anti-estrogenic activity was reported previously by the authors. Objective: In order to increase the potency of their anti-estrogenic effect and to clarify their binding way to estrogen receptor on a molecular level, several derivatives of both compounds will be prepared and a docking study of the original compounds and their derivatives on estrogen… Expand
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Mansonone G (MG), a naturally occurring quinone-containing compound, and its semi-synthetic ether derivatives were subjected to investigate the anticancer effects on human NSCLC cell lines expressing wild-type EGFR and mutant EGFR to reveal that MG3 induces a caspase-dependent apoptosis mechanism. Expand
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