Anti-epileptic medications

  title={Anti-epileptic medications},
  author={Megan E. Maroney and Marija Markovic},
  journal={Side Effects of Drugs Annual},



Phenytoin intoxication associated with omeprazole administration in a child with defective CYP2C9

A case of phenytoin intoxication in a child with defective CYP2C9, after omeprazole administration is described, and it is worth noting that very frequently administered drugs, such as proton pump inhibitors, compete with pheny toin for CYP 2C19-mediated metabolism.

Valproic Acid-Induced Thrombocytopenia-Related Spontaneous Systemic Bleeding

To the best of the authors' knowledge, this is the first case report of spontaneous systemic bleeding due to valproic acid-induced thrombocytopenia in the setting of normal fibrinogen levels.

HLA-A∗24:02 associated with lamotrigine-induced cutaneous adverse drug reactions

HLA-A∗24:02 may be a risk factor for LTG-cADRs, according to a systematic review and meta-analysis of the literature conducted in several electronic database systems.

A Case of Pregabalin-Induced Parkinsonism

A 53-year-old female patient with the signs of parkinsonism following pregabalin treatment is presented, and the symptoms relieved after the treatment stopped at a follow-up of 10 days.

Carbamazepine‐induced Stevens‐Johnson syndrome in a patient with history of methotrexate‐induced mast cell activation syndrome

Doctors would like to alert all physicians that carbamazepine should be avoided in any patient with a previous history of drug reaction such as mast cell activation syndrome.

Effects of lacosamide and carbamazepine on lipids in a randomized trial

The effects of anticonvulsants on lipids are the subject of considerable concern and investigation, but there are almost no data on this issue from randomized trials. We evaluated serum lipid

A Rare, Unreported Cognitive Side Effect of Topiramate: Do We Know It All Yet?

A case of drug-induced amnesia is presented, with support from Naranjo Nomogram, as a hitherto unreported side effect of topiramate, with the aim of improving patient outcome by timely recognition, and discontinuation of the offending drug, as the side effect was fortunately found to be reversible.