Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists

  title={Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists},
  author={Brian S. Meldrum and Maria H. Millan and S M Patel and Giovambattista De Sarro},
  journal={Journal of Neural Transmission},
The role of excitatory synaptic activity at various brain regions in the development and spread of seizure activity has been investigated by the focal microinjection of 2-amino-7-phosphono-heptanoate (2-APH), a selective antagonist at the N-methyl-D-aspartate preferring receptor, orγ-D-glutamylaminomethyl sulphonate (GAMS), a partially selective antagonist at the kainate receptor. In genetically epilepsy prone rats the seizure response to a loud sound is most effectively suppressed by focal… 

Local distribution and toxicity of prolonged hippocampal infusion of muscimol.

Targeted modulation of neuronal activity is a reasonable research strategy for the investigation and treatment of medically intractable epilepsy.

Effects of some synthetic kynurenines on brain amino acids and nitric oxide after pentylenetetrazole administration to rats

A new family of anticonvulsant drugs that affect mainly to nitric oxide production in the brain is revealed, driven by the dose‐dependent reduction of brain nitrite levels induced by PTZ.

Changes in Cytochrome Oxidase in the Piriform Cortex after Status Epilepticus in Adult Rats

Activity of the cytochrome oxidase is studied separately in the rostral and caudal parts of the piriform cortex after lithium chloride–pilocarpine–induced SE in adult rats to indicate that the early activity of the Piriform cortex should be accompanied by increased adenosine triphosphate (ATP) production.

Glutamatergic NMDA Receptor as Therapeutic Target for Depression.

Seizures and the Developing Brain

This work has shown that subcortical nuclei, such as the substantia nigra, control the expression and propagation of neurons and, in certain situations, this may be detrimental for brain development.

Bypassing the Blood–Brain Barrier: Direct Intracranial Drug Delivery in Epilepsies

Although an invasive procedure, bypassing the BBB by targeted intracranial drug delivery is an attractive approach to circumvent BBB-associated drug resistance mechanisms and to lower the risk of systemic and neurologic adverse effects.

Electrophysiological properties of human hypothalamic hamartomas

It is suggested that human HH tissues, associated with gelastic seizures, contained predominantly small GABAergic inhibitory neurons that exhibited intrinsic “pacemaker‐like” behavior.



A crucial epileptogenic site in the deep prepiriform cortex

It is reported that manipulations of excitatory amino acid transmission and cholinergic transmission can also elicit seizures from this site, and this region is therefore a site of action for the epileptogenic effects of neuroactive agents with diverse mechanisms of action.

Evidence implicating substantia nigra in regulation of kindled seizure threshold

The suppression of limbic seizures indicates that this brainstem nucleus can regulate the intrinsic neuronal excitability of hemispheric sites and is interpreted to indicate that the SN is the site at which the GABA agonists and lesions act to raise the threshold for kindled seizures.

Substantia nigra: site of anticonvulsant activity mediated by gamma-aminobutyric acid.

Local injection of GABA agonists into the midbrain provided seizure protection without a widespread augmentation of GABA-mediated activity throughout the brain and without impairing either alertness or motor function.

A physiological study of epileptic seizures following cortical stimulation in animals and its application to human clinics.

  • T. Hayashi
  • Biology
    The Japanese journal of physiology
  • 1952
The method of chemical stimulation can fractionate the action of the motor cells in experiments on the central nervous system, and elucidate the path of each system.

Distribution of N-methyl-D-aspartate-sensitive L-[3H]glutamate-binding sites in rat brain

  • D. MonaghanC. Cotman
  • Biology
    The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1985
The distribution of NMDA-sensitive L-[3H]glutamate-binding sites suggests that the NMDA receptor represents a major, distinct subset of excitatory amino acid receptors and indicates regions in which neurotransmission may be mediated or modulated by this receptor.

Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra.

Role of brain norepinephrine in audiogenic seizure in the rat.

It is proposed that NE exerts all inhibitory effect in the brain which tends to limit spread of seizure discharge, which implies that depletion of brain NE and/or DA is associated with increased severity of AGS.