Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists

@article{Meldrum2005AntiepilepticEO,
  title={Anti-epileptic effects of focal micro-injection of excitatory amino acid antagonists},
  author={Brian S. Meldrum and Maria H. Millan and S M Patel and Giovambattista De Sarro},
  journal={Journal of Neural Transmission},
  year={2005},
  volume={72},
  pages={191-200}
}
The role of excitatory synaptic activity at various brain regions in the development and spread of seizure activity has been investigated by the focal microinjection of 2-amino-7-phosphono-heptanoate (2-APH), a selective antagonist at the N-methyl-D-aspartate preferring receptor, orγ-D-glutamylaminomethyl sulphonate (GAMS), a partially selective antagonist at the kainate receptor. In genetically epilepsy prone rats the seizure response to a loud sound is most effectively suppressed by focal… 

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