Anti-epileptic drug treatment in children: hyperhomocysteinaemia, B-vitamins and the 677C-->T mutation of the methylenetetrahydrofolate reductase gene.

@article{Vilaseca2000AntiepilepticDT,
  title={Anti-epileptic drug treatment in children: hyperhomocysteinaemia, B-vitamins and the 677C-->T mutation of the methylenetetrahydrofolate reductase gene.},
  author={Mar{\'i}a Ant{\`o}nia Vilaseca and Eug{\`e}nia Monr{\'o}s and Rafael Artuch and Catrina Colom{\'e} and Carme Farr{\'e} and Carme Valls and Esther Cardo and M Pineda},
  journal={European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society},
  year={2000},
  volume={4 6},
  pages={
          269-77
        }
}
  • M. VilasecaE. Monrós M. Pineda
  • Published 1 November 2000
  • Medicine, Psychology, Biology
  • European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society
The aim of the study was to observe the influence of carbamazepine and valproic acid on plasma total homocysteine and B-vitamin status and the gene-drug interaction with the 677C-->T mutation of the methylenetetrahydrofolate reductase (MTHFR) gene. Plasma total homocysteine concentrations were determined in 136 epileptic children taking anti-epileptic drugs as monotherapy. Nutritional (folate, B12 and B6 vitamins) and genetic (MTHFR 677 C-->T) determinants of plasma homocysteine were studied in… 

Vitamin B6 and homocysteine levels in carbamazepine treated epilepsy of Khyber Pakhtunkhwa.

A significant decline in vitamin B6 levels and hyperhomocysteinemia were found in variant genotypes of MTHFR (C677T, A1298C) and GABRG2 (C588T, C315T) genes in carbamazepine resistant epilepsy in the population of Khyber Pakhtunkhwa.

Epilepsy , Hyperhomocysteinemia and Mutant Methylenetetrahydrofolate Reductase Gene

Hyperhomocysteine level in epileptic patients is evaluated in comparison to control group, and the possible relation between hyperhomocysteinemia and (MTHFR) gene and clinical data is investigated to avoid its devastating consequences.

Methylenetetrahydrofolate reductase gene polymorphism and clinical importance in epilepsy patients using valproic acid, carbamazepine and levetiracetam

VPA should not be used in the presence of other thrombophilic risk factors because of hyperhomocysteinemia, and vitamin B12 therapy is necessary on CBZ and on combinedCBZ and VPA.

Assessment of asymmetric dimethylarginine and homocysteine in epileptic children receiving antiepileptic drugs

Long-term use of antiepileptic drugs, especially old-generation polytherapy, can increase lipid profiles, homocysteine levels, ADMA, and carotid intima-media thickness compared to the minimal effect of new AEDs.

Homocysteine Metabolism and Hematological Parameters in Early Stage of Phenytoin Treated Epileptic Children.

Phenytoin monotherapy may cause a significant increase in the levels of serum homocysteine and a significant decrease in the serum folate and vitamin B12 levels in children with epilepsy, and the significant changes in above mentioned parameters occur early in the course of treatment.

Effect of carbamazepine therapy on homocysteine, vitamin B12 and folic acid levels in children with epilepsy

6 months of carbamazepine therapy did not cause significant change in serum levels of homocysteine, vitamin B12 and folic acid, and there was no effect of age, sex or dietary pattern on homocy steine levels.
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