Anti-epidermal growth factor receptor monoclonal antibodies in cancer treatment.

  title={Anti-epidermal growth factor receptor monoclonal antibodies in cancer treatment.},
  author={J Capdevila and E Elez and T Macarulla and Francisco Javier Chacartegui Ramos and Manuel Ruiz-Echarri and Josep Tabernero},
  journal={Cancer treatment reviews},
  volume={35 4},
Although the prognosis of cancer remains poor recent advances in the diagnostic methods, new approaches in surgical procedures and the development of new therapeutic agents have had a significant impact in the outcome of cancer patients. A better understanding of the molecular pathways that characterize cell growth, apoptosis, angiogenesis and invasion has provided novel targets in cancer therapy. The epidermal growth factor receptor (EGFR) mediated signal transduction has been one of the most… CONTINUE READING