Anti-endothelial cell antibody binding makes negatively charged phospholipids accessible to antiphospholipid antibodies.

@article{Bordron1998AntiendothelialCA,
  title={Anti-endothelial cell antibody binding makes negatively charged phospholipids accessible to antiphospholipid antibodies.},
  author={Anne Bordron and Maryvonne Dueymes and Yehuda Levy and Christophe Jamin and Lea Ziporen and J. C. Piette and Yehuda Shoenfeld and Pierre Youinou},
  journal={Arthritis and rheumatism},
  year={1998},
  volume={41 10},
  pages={1738-47}
}
OBJECTIVE Anti-endothelial cell autoantibodies (AECA) are often associated with antibodies to anionic phospholipids (PL), such as phosphatidylserine (PS). Yet, beta2-glycoprotein I (beta2GPI)-dependent anti-PL antibodies (aPL) do not have access to their target antigens on the membrane of endothelial cells (EC). Given that AECA are capable of exposing PS and, thereby, initiating apoptosis, we explored the relationships between AECA, beta2GPI, and aPL on the surface of EC. METHODS Human EC… CONTINUE READING
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