Anti-endothelial cell antibodies from lupus patients bind to apoptotic endothelial cells promoting macrophage phagocytosis but do not induce apoptosis.

@article{Williams2005AntiendothelialCA,
  title={Anti-endothelial cell antibodies from lupus patients bind to apoptotic endothelial cells promoting macrophage phagocytosis but do not induce apoptosis.},
  author={Julie M. Williams and R. L. Colman and Christopher J. Brookes and Caroline O. S. Savage and Lorraine Harper},
  journal={Rheumatology},
  year={2005},
  volume={44 7},
  pages={879-84}
}
OBJECTIVE Anti-endothelial cell antibodies (AECA) have been reported to induce apoptosis. We investigated the induction of apoptosis by these autoantibodies and their involvement in the removal of apoptotic cells. METHODS AECA isolated from patients with active systemic lupus erythematosus (SLE) were incubated with human umbilical vein endothelial cells (HUVECs). AECA-positive sera were identified using a cell-based ELISA. Apoptosis was measured by morphology and phosphatidylserine… CONTINUE READING