Anti-endothelial cell IgG fractions from systemic lupus erythematosus patients bind to human endothelial cells and induce a pro-adhesive and a pro-inflammatory phenotype in vitro.

@article{Papa1999AntiendothelialCI,
  title={Anti-endothelial cell IgG fractions from systemic lupus erythematosus patients bind to human endothelial cells and induce a pro-adhesive and a pro-inflammatory phenotype in vitro.},
  author={Nicoletta Del Papa and Elena Raschi and Gabriella Moroni and Paola Panzeri and Maria O Borghi and Claudio Ponticelli and Anǵela Tincani and Genesio Balestrieri and Pier Luigi Meroni},
  journal={Lupus},
  year={1999},
  volume={8 6},
  pages={
          423-9
        }
}
Affinity purified immunoglobulin G (IgG) fractions from systemic lupus erythematosus (SLE) patients positive for anti-endothelial cell antibodies (AECA) bind human umbilical vein endothelial cell (HUVEC) monolayers. In vitro incubation of serial protein concentrations of SLE AECA IgG induces a dose-dependent endothelial activation: i) increase of functional adhesion of the monocytic cell line U937; ii) upregulation of E-Selectin, ICAM-1, VCAM-1 expression evaluated by a cell solid-phase enzyme… CONTINUE READING
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