Anti-emetics and cancer chemotherapy.


zone (CTZ) and some of the pathways involved. However, until the late 1960s, anti-emesis in the cancer field was largely empirical and often poorly effective. The pioneering clinical studies of Gralla et al. (1981) and Sallan et al. (1980) into the use of high-dose metoclopramide and the cannabinoids respectively provided not only a scientific framework for conducting anti-emetic studies but also demonstrated significant advances in anti-emetic control. The rational implementation of anti-emetic therapy should be based upon scientific data and hence it is appropriate to summarise the current state of knowledge. Vomiting is recognised to be in physiological terms a protective mechanism for removing harmful substances which have been accidentally ingested. Animals such as rats with a highly developed olefactory apparatus do not vomit as accidental ingestion is presumably highly unlikely. However,

DOI: 10.1038/bjc.1990.76

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@article{Leonard1990AntiemeticsAC, title={Anti-emetics and cancer chemotherapy.}, author={R. C. F. Leonard and Michael Soukop}, journal={British Journal of Cancer}, year={1990}, volume={61}, pages={349 - 350} }