Anti-dyskinetic effect of anpirtoline in animal models of L-DOPA-induced dyskinesia.

  title={Anti-dyskinetic effect of anpirtoline in animal models of L-DOPA-induced dyskinesia.},
  author={Erwan B{\'e}zard and Ana Patricia Mu{\~n}oz and Elisabetta Tronci and Elsa Y. Pioli and Qin Li and Gr{\'e}gory Porras and Anders Bj{\"o}rklund and Manolo Carta},
  journal={Neuroscience research},
  volume={77 4},
The serotonin system has emerged as a potential target for anti-dyskinetic therapy in Parkinson's disease. In fact, serotonin neurons can convert L-DOPA into dopamine, and mediate its synaptic release. However, they lack a feedback control mechanism able to regulate synaptic dopamine levels, which leads to un-physiological stimulation of post-synaptic striatal dopamine receptors. Accordingly, drugs able to dampen the activity of serotonin neurons can suppress L-DOPA-induced dyskinesia in animal… CONTINUE READING
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Contribution of the striatum to the effects of 5 - HT 1 A receptor stimulation in L - DOPA - treated hemiparkinsonian rats

  • K. L. Eskow, C. J. Barnum, K. B. Dupre, T. Deak
  • J . Neurosci . Res .
  • 2009
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