Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis.

  title={Anti-dsDNA antibodies bind to mesangial annexin II in lupus nephritis.},
  author={Susan Yung and Kwok Fan Cheung and Qing Zhang and Tak Mao Chan},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={21 11},
Production of anti-dsDNA antibodies is a hallmark of lupus nephritis, but how these antibodies deposit in organs and elicit inflammatory damage remains unknown. In this study, we sought to identify antigens on the surface of human mesangial cells (HMC) that mediate the binding of human anti-dsDNA antibodies and the subsequent pathogenic processes. We isolated anti-dsDNA antibodies from patients with lupus nephritis by affinity chromatography. We used multiple methods to identify and… CONTINUE READING

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