Anti-digoxin Fab fragments in cardiotoxicity induced by ingestion of yellow oleander: a randomised controlled trial

@article{Eddleston2000AntidigoxinFF,
  title={Anti-digoxin Fab fragments in cardiotoxicity induced by ingestion of yellow oleander: a randomised controlled trial},
  author={Michael Eddleston and S. Rajapakse and Rajakanthan and S Jayalath and L Sj{\"o}str{\"o}m and Wijeyasingam Samuel Santharaj and P. N. Thenabadu and M H Rezvi Sheriff and David A Warrell},
  journal={The Lancet},
  year={2000},
  volume={355},
  pages={967-972}
}
BACKGROUND Severe cardiac glycoside cardiotoxicity after ingestion of yellow oleander seeds is an important problem in rural areas of Sri Lanka. Currently, patients must be transferred to the capital for temporary cardiac pacing. We did a randomised controlled trial to investigate whether anti-digoxin Fab could reverse serious oleander-induced arrhythmias. METHODS After a preliminary dose-finding study, 66 patients who presented to hospital with a serious cardiac arrhythmia were randomised to… Expand
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