Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

@article{Maianti2014AntidiabeticAO,
  title={Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones},
  author={Juan Pablo Maianti and Amanda K. McFedries and Zachariah H Foda and Ralph E Kleiner and Xiu Quan Du and Malcolm A Leissring and Wei-Jen Tang and Maureen J. Charron and Markus A. Seeliger and Alan Saghatelian and David R Liu},
  journal={Nature},
  year={2014},
  volume={511},
  pages={94-98}
}
Despite decades of speculation that inhibiting endogenous insulin degradation might treat type-2 diabetes, and the identification of IDE (insulin-degrading enzyme) as a diabetes susceptibility gene, the relationship between the activity of the zinc metalloprotein IDE and glucose homeostasis remains unclear. Although Ide–/– mice have elevated insulin levels, they exhibit impaired, rather than improved, glucose tolerance that may arise from compensatory insulin signalling dysfunction. IDE… CONTINUE READING
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