Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells.

  title={Anti-diabetic actions of glucagon-like peptide-1 on pancreatic beta-cells.},
  author={Young-Sun Lee and Hee-Sook Jun},
  journal={Metabolism: clinical and experimental},
  volume={63 1},
Glucagon-like peptide-1 (GLP-1), an incretin hormone, is released from intestinal L-cells in response to nutrients. GLP-1 lowers blood glucose levels by stimulating insulin secretion from pancreatic beta-cells in a glucose-dependent manner. In addition, GLP-1 slows gastric emptying, suppresses appetite, reduces plasma glucagon, and stimulates glucose disposal, which are beneficial for glucose homeostasis. Therefore, incretin-based therapies such as GLP-1 receptor agonists and inhibitors of… CONTINUE READING
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