Anti-cytokine strategies for the treatment of cancer-related anorexia and cachexia.

  title={Anti-cytokine strategies for the treatment of cancer-related anorexia and cachexia.},
  author={Fabio Penna and Valerio Giacomo Minero and Domiziana Costamagna and Gabriella Bonelli and Francesco Maria Baccino and Paola Costelli},
  journal={Expert opinion on biological therapy},
  volume={10 8},
IMPORTANCE OF THE FIELD Cachexia is a syndrome characterized by body weight loss and metabolic abnormalities. It is a frequent feature of patients affected by chronic pathologies, including cancer. Neoplastic patients with cachexia show increased morbidity and mortality rates, benefit less from antineoplastic therapies, and have a poorer quality of life. Among the general mechanisms proposed to account for cachexia, anorexia and altered homeostasis of hormones and cytokines appear to play a… CONTINUE READING
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