Anti-copper therapies in Alzheimer's disease: new concepts.


Alzheimer's disease (AD) is a heterogeneous and progressive neurodegenerative disorder. The recent Metal Hypothesis states that the interaction of Amyloid beta (Abeta, the main constituent of senile plaques) with transition metals is at the basis of AD neurodegeneration. This hypothesis is based on in vitro studies demonstrating that metals (copper, zinc… (More)


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@article{Squitti2009AnticopperTI, title={Anti-copper therapies in Alzheimer's disease: new concepts.}, author={Rosanna Squitti and Giancarlo Zito}, journal={Recent patents on CNS drug discovery}, year={2009}, volume={4 3}, pages={209-19} }