Anti-citrullinated protein antibodies bind surface-expressed citrullinated Grp78 on monocyte/macrophages and stimulate tumor necrosis factor alpha production.

@article{Lu2010AnticitrullinatedPA,
  title={Anti-citrullinated protein antibodies bind surface-expressed citrullinated Grp78 on monocyte/macrophages and stimulate tumor necrosis factor alpha production.},
  author={Ming-Chi Lu and N E Lai and H Yu and Hsien-Bin Huang and Song-Chou Hsieh and C G Yu},
  journal={Arthritis and rheumatism},
  year={2010},
  volume={62 5},
  pages={1213-23}
}
OBJECTIVE Anti-citrullinated protein antibodies (ACPAs), which are the most specific autoantibody marker in patients with rheumatoid arthritis (RA), correlate with disease activity; however, the role of ACPAs in RA pathogenesis has not been elucidated. We hypothesized that ACPAs may directly stimulate mononuclear cells to produce inflammatory cytokines. Thus, we identified cognate antigens of ACPAs on monocyte/macrophages and examined their immunopathologic roles in the pathogenesis of RA… CONTINUE READING