Anti-chemokine small molecule drugs: a promising future?

  title={Anti-chemokine small molecule drugs: a promising future?},
  author={Amanda E. I. Proudfoot and Christine A. Power and Matthias K. Schwarz},
  journal={Expert opinion on investigational drugs},
  volume={19 3},
IMPORTANCE OF THE FIELD Chemokines have principally been associated with inflammation due to their role in the control of leukocyte migration, but just over a decade ago chemokine receptors were also identified as playing a pivotal role in the entry of the HIV virus into cells. Chemokines activate seven transmembrane G protein-coupled receptors, making them extremely attractive therapeutic targets for the pharmaceutical industry. AREAS COVERED IN THIS REVIEW Although there are now a large… CONTINUE READING


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