Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice.

@article{Rotolo2012AnticeramideAP,
  title={Anti-ceramide antibody prevents the radiation gastrointestinal syndrome in mice.},
  author={Jimmy A. Rotolo and Branka Stancevic and Jianguo Zhang and Guoqiang Hua and John Fuller and Xianglei Yin and Adriana Haimovitz-Friedman and Kisu Kim and Ming Qian and Marina Card{\'o}-Vila and Zvi Fuks and Renata Pasqualini and Wadih Arap and Richard N. Kolesnick},
  journal={The Journal of clinical investigation},
  year={2012},
  volume={122 5},
  pages={1786-90}
}
Radiation gastrointestinal (GI) syndrome is a major lethal toxicity that may occur after a radiation/nuclear incident. Currently, there are no prophylactic countermeasures against radiation GI syndrome lethality for first responders, military personnel, or remediation workers entering a contaminated area. The pathophysiology of this syndrome requires depletion of stem cell clonogens (SCCs) within the crypts of Lieberkühn, which are a subset of cells necessary for postinjury regeneration of gut… CONTINUE READING
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