Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats.

@article{Nahas2009AnticeramidaseLA,
  title={Anti-ceramidase LCL385 acutely reduces BCL-2 expression in the hippocampus but is not associated with an increase of learned helplessness in rats.},
  author={Ziad Nahas and Yan Jiang and Youssef H. Zeidan and Alicja Bielawska and Zdzislaw M. Szulc and Lindsay Devane and Peter W. Kalivas and Yusuf A. Hannun},
  journal={Behavioural brain research},
  year={2009},
  volume={197 1},
  pages={41-4}
}
UNLABELLED Evidence from in situ studies supports the role of anti-apoptotic factors in the antidepressant responses of certain psychotropics. The availability of anti-ceramidase pro-apoptocic compound (LCL385) provides an opportunity to test in vivo the relation between hippocampal apopotosis and learned helplessness. METHOD 40 Sprague-Dawley male rodents underwent an FST after a treatment with LCL385, desipramine (DMI), or placebo (SAL) over 3 days. Behavioral responses, including… CONTINUE READING