Anti-carbohydrate antibodies elicited by polyvalent display on a viral scaffold.

  title={Anti-carbohydrate antibodies elicited by polyvalent display on a viral scaffold.},
  author={Eiton Kaltgrad and Sayam Sen Gupta and Sreenivas Punna and C Huang and A Chang and Chi-Huey Wong and M G Finn and Ola Blixt},
  journal={Chembiochem : a European journal of chemical biology},
  volume={8 12},
Tetra- and hexasaccharides were arrayed on the exterior surface of cowpea mosaic virus by using a copper-catalyzed azide-alkyne cycloaddition reaction. Inoculation of chickens with these virus conjugates gave rise to large quantities of polyclonal anti-glycan IgY antibodies that displayed excellent avidity and specificity on analysis with printed glycan microarrays. Avian IgY antibodies are produced in significantly higher yield than is possible for mouse or rabbit IgG, and exhibit reduced… CONTINUE READING


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