Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines.

@article{Michaelis2010AnticancerEO,
  title={Anti-cancer effects of artesunate in a panel of chemoresistant neuroblastoma cell lines.},
  author={Martin Michaelis and Malte Christian Kleinschmidt and Susanne Barth and Florian Rothweiler and Janina Geiler and Rainer Breitling and Bernd Mayer and Hedwig E. Deubzer and Olaf Witt and Joerg Kreuter and Hans Wilhelm Doerr and Jaroslav Cin{\'a}tl and Jindrich Cinatl},
  journal={Biochemical pharmacology},
  year={2010},
  volume={79 2},
  pages={
          130-6
        }
}
Artemisinin derivatives are well-tolerated anti-malaria drugs that also exert anti-cancer activity. Here, we investigated artemisinin and its derivatives dihydroartemisinin and artesunate in a panel of chemosensitive and chemoresistant human neuroblastoma cells as well as in primary neuroblastoma cultures. Only dihydroartemisinin and artesunate affected neuroblastoma cell viability with artesunate being more active. Artesunate-induced apoptosis and reactive oxygen species in neuroblastoma cells… CONTINUE READING
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