Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway

@article{Wu2017AnticancerEO,
  title={Anti-cancer effect of danshen and dihydroisotanshinone I on prostate cancer: targeting the crosstalk between macrophages and cancer cells via inhibition of the STAT3/CCL2 signaling pathway},
  author={Ching-Yuan Wu and Y. Yang and Yin-Yin Lin and Feng-Che Kuan and Yu-Shin Lin and Wei‐Yu Lin and Ming-Yen Tsai and Jia-Jing Yang and Yu-Ching Cheng and Li-Hsin Shu and Ming-Chu Lu and Y. Chen and Kuan-Der Lee and H. Kang},
  journal={Oncotarget},
  year={2017},
  volume={8},
  pages={40246 - 40263}
}
Danshen (Salvia miltiorrhiza Bunge) is widely used in traditional Chinese medicine. In our study, the in vivo protective effect of danshen in prostate cancer patients was validated through data from the National Health Insurance Research Database in Taiwan. In vitro, we discovered that dihydroisotanshinone I (DT), a bioactive compound present in danshen, can inhibit the migration of both androgen-dependent and androgen-independent prostate cancer cells. In addition, we noted that DT… Expand
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