Anti-cancer drug characterisation using a human cell line panel representing defined types of drug resistance.

@article{Dhar1996AnticancerDC,
  title={Anti-cancer drug characterisation using a human cell line panel representing defined types of drug resistance.},
  author={Sumeer Dhar and P. -{\AA}. Nygren and K. Csoka and J. Botling and Karin Svedberg Nilsson and Rolf Larsson},
  journal={British Journal of Cancer},
  year={1996},
  volume={74},
  pages={888 - 896}
}
Differential drug response in a human cell line panel representing defined types of cytotoxic drug resistance was measured using the non-clonogenic fluorometric microculture cytotoxicity assay (FMCA). In total 37 drugs were analysed; eight topoisomerase II inhibitors, eight anti-metabolites, eight alkylating agents, eight tubulin-active agents and five compounds with other or unknown mechanisms of action, including one topoisomerase I inhibitor. Correlation analysis of log IC50 values obtained… CONTINUE READING

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